Shared heritability of adiponectin and the MetS The genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome related traits Running Title: Shared heritability of adiponectin and the MetS
نویسندگان
چکیده
Dept.Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. Dept. Epidemiology, Erasmus MC Rotterdam, the Netherlands. Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia. Dept. of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands. Dept. Clinical Chemistry, Leiden University Medical Center, Leiden, the Netherlands. Dept. Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
منابع مشابه
Adiponectin: an adipokine with protective features against metabolic syndrome
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of ...
متن کاملGenetic Architecture of Plasma Adiponectin Overlaps With the Genetics of Metabolic Syndrome–Related Traits
OBJECTIVE Adiponectin, a hormone secreted by adipose tissue, is of particular interest in metabolic syndrome, because it is inversely correlated with obesity and insulin sensitivity. However, it is not known to what extent the genetics of plasma adiponectin and the genetics of obesity and insulin sensitivity are interrelated. We aimed to evaluate the heritability of plasma adiponectin and its g...
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Dear Editor, The recent article by Mohammadzadeh et al.[1] on the latest issue of this Journal showed that the T allele +276G/T SNP of ADIPOQ gene is more associated with the increasing risk of coronary artery disease (CAD) in subjects with type 2 diabetes. Adipocytes were described in myocardial tissue of CAD patients and their role recently discussed[2,3]. Susceptibility to CAD by polymorp...
متن کاملMenopause impacts the relation of plasma adiponectin levels with the metabolic syndrome.
OBJECTIVE Plasma adiponectin is negatively correlated with metabolic syndrome (MetS) components obesity and insulin sensitivity. Here, we set out to evaluate the effect of menopause on the association of plasma adiponectin with MetS. DESIGN Data on plasma adiponectin and MetS were available from 2256 individuals participating in the Erasmus Rucphen Family study. Odds ratios for MetS were calc...
متن کاملPlasma Adiponectin Concentration and Its Association with Metabolic Syndrome in Patients with Heart Failure
PURPOSE Plasma adiponectin concentrations are inversely related with metabolic syndrome (MetS), and MetS is associated with increased risk for heart failure (HF). However, the relationship between adiponectin and MetS in HF remains undetermined. Therefore, we tested whether MetS was associated with the degree of plasma adiponectin concentrations in HF patients. MATERIALS AND METHODS One hundr...
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